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Враг, способный стать другом. К вопросу о пользе алкоголя

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Враг, способный стать другом. К вопросу о пользе алкоголя

Журнал "Медицинский совет. Терапия" №6 2018



А.О. Буеверов1,2, д.м.н., профессор, П.О. Богомолов2
1 Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский университет)
2 Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского

A.O. Bueverov1,2, MD, Prof., P.O. Bogomolov2
1 Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)
2 Vladimirsky Moscow Regional Research Clinical Institute

When an enemy becomes a friend. On the benefits of alcohol consumption

В то время как высокие дозы алкоголя являются доказанным фактором риска поражения различных органов и систем, в отношении малых и умеренных доз накоплены противоположные данные. Так, регулярное употребление спиртных напитков в небольших количествах уменьшает вероятность развития ишемической болезни сердца, инсульта, сахарного диабета 2-го типа, неалкогольной жировой болезни печени, остеопороза и некоторых других заболеваний, а также снижает общую смертность. Малые дозы алкоголя подавляют активность воспаления и перекисного окисления, нормализуют гемокоагуляцию, улучшают липидный профиль, благоприятно влияют на тонус сосудистой стенки и чувствительность тканей к инсулину. Наиболее изучены позитивные эффекты вина, что обычно объясняется содержанием в нем полифенолов, в меньшей степени – пива; однако следует учитывать, что в большинстве проведенных исследований фигурировали разные виды спиртных напитков. Таким образом, можно признать нецелесообразным полный запрет на употребление алкоголя лицам без зависимости и специфических органных поражений.

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Список литературы

1. Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet, 2009, 373: 2223-2233.

2. Movva R, Figueredo VM. Alcohol and the heart: to abstain or not to abstain? Int J Cardiol, 2013, 164: 267-276.

3. Fung P, Pyrsopoulos N. Emerging concepts in alcoholic hepatitis. World J Hepatol, 2017, 9: 567-585.

4. Klatsky AL, Friedman GD, Siegelaub AB. Alcohol and mortality. A ten-year Kaiser-Permanente experience. Ann Intern Med, 1981, 95: 139-145.

5. Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med, 1988, 319: 267-273.

6. Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G. Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med, 2006, 166: 2437-2445.

7. Costanzo S, Di Castelnuovo A, Donati MB, Iacoviello L, de Gaetano G. Alcohol consumption and mortality in patients with cardiovascular disease: a meta-analysis. J Am Coll Cardiol, 2010, 55: 1339-1347.

8. Friedman LA, Kimball AW. Coronary heart disease mortality and alcohol consumption in Framingham. Am J Epidemiol, 1986, 124: 481- 489.

9. Mukamal KJ, Chen CM, Rao SR, Breslow RA. Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. J Am Coll Cardiol, 2010, 55: 1328-1335.

10. Hvidtfeldt UA, Tolstrup JS, Jakobsen MU et al. Alcohol intake and risk of coronary heart disease in younger, middle-aged, and older adults. Circulation, 2010, 121: 1589-1597.

11. Mukamal KJ, Chiuve SE, Rimm EB. Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles. Arch Intern Med, 2006, 166: 2145-2150.

12. Bazzano LA, Gu D, Reynolds K et al. Alcohol consumption and risk of coronary heart disease among Chinese men. Int J Cardiol, 2009, 135: 78-85.

13. Inoue M, Nagata C, Tsuji I et al. Impact of alcohol intake on total mortality and mortality from major causes in Japan: a pooled analysis of six large-scale cohort studies. J Epidemiol Community Health, 2010, doi: 10.1136/jech.2010.121830.

14. Djousse L, Lee IM, Buring JE, Gaziano JM. Alcohol consumption and risk of cardiovascular disease and death in women: potential mediating mechanisms. Circulation, 2009, 120: 237- 244.

15. Hart CL, Smith GD, Hole DJ, Hawthorne VM. Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up. BMJ, 1999, 318: 1725-1729.

16. Deev A, Shestov D, Abernathy J, Kapustina A, Muhina N, Irving S. Association of alcohol consumption to morality in middle-aged U.S. and Russian men and women. Ann Epidemiol, 1998, 8: 147-153.

17. Roerecke M, Rehm J. Irregular heavy drinking occasions and risk of ischemic heart disease: a systematic review and meta-analysis. Am J Epidemiol, 2010, 171: 633-644.

18. Stockwell T, Zhao J, Panwar S, Roemer A, Naimi T, Chikritzhs T. Do «moderate» drinkers have reduced mortality risk? A systematic review and meta-ana lysis of alcohol consumption and all-cause mortality J Stud. Alcohol Drugs, 2016, 77: 185-198.

19. Zhao J, Stockwell T, Roemer A, Naimi T, Chikritzhs T. Alcohol consumption and mortality from coronary heart disease: an updated meta-analysis of cohort studies. J Stud Alcohol Drugs, 2017, 78: 375-386.

20. Djousse L, Gaziano JM. Alcohol consumption and risk of heart failure in the Physicians’ Health Study I. Circulation, 2007, 115: 34-39.

21. O’Keefe JH, Bhatti SK, Bajwa A, DiNicolantonio JJ, Lavie CJ. Alcohol and cardiovascular health: the dose makes the poison…or the remedy. Mayo Clin Proc, 2014, 89: 382-393.

22. Padilla H, Gaziano J Michael, Djousse L. Alcohol consumption and risk of heart failure: a meta-analysis. Phys Sportsmed, 2010, 38: 84-89.

23. Klatsky AL, Chartier D, Udaltsova N et al. Alcohol drinking and risk of hospitalization for heart failure with and without associated coronary artery disease. Am J Cardiol, 2005, 96: 346-351.

24. Gargiulo G, Testa G, Cacciatore F, Mazzella F, Galizia G, Della-Morte D et al. Moderate alcohol consumption predicts long-term mortality in elderly subjects with chronic heart failure. J Nutr Health Aging, 2013, 17: 480-485.

25. Nicolas JM, Fernandez-Sola J, Estruch R et al. The effect of controlled drinking in alcoholic cardiomyopathy. Ann Intern Med, 2002, 136: 192-200.

26. Djousse L, Levy D, Benjamin EJ et al. Long-term alcohol consumption and the risk of atrial fibrillation in the Framingham Study. Am J Cardiol, 2004, 93: 710-713.

27. Mukamal KJ, Tolstrup JS, Friberg J, Jensen G, Gronbaek M. Alcohol consumption and risk of atrial fibrillation in men and women: the Copenhagen City Heart Study. Circulation, 2005, 112: 1736-1742.

28. Stephan LS, Almeida ED, Markoski MM, Garavaglia J, Marcadenti A. Red wine, resveratrol and atrial fibrillation. Nutrients, 2017, 9: pii: E1190.

29. Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, He J. Alcohol consumption and risk of stroke: a meta-analysis. JAMA, 2003, 289: 579-588.

30. Zhang C, Qin YY, Chen Q, Jiang H, Chen XZ, Xu CL et al. Alcohol intake and risk of stroke: a dose-response meta-analysis of prospective studies. Int J Cardiol, 2014, 174: 669-677.

31. Vliegenthart R, Geleijnse JM, Hofman A et al. Alcohol consumption and risk of peripheral arterial disease: the Rotterdam study. Am J Epidemiol, 2002, 155: 332-338.

32. Volcik KA, Ballantyne CM, Fuchs FD, Sharrett AR, Boerwinkle E. Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC study. Ann Epidemiol, 2008, 18: 101-107.

33. Brien SE, Ronksley PE, Turner BJ, Mukamal KJ, Ghali WA. Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ, 2011, 342: d636.

34. Magnus P, Bakke E, Hoff DA et al. Controlling for high-density lipoprotein cholesterol does not affect the magnitude of the relationship between alcohol and coronary heart disease. Circulation, 2011, 124: 2296-2302.

35. Halanych JH, Safford MM, Kertesz SG et al. Alcohol consumption in young adults and incident hypertension: 20-year follow-up from the Coronary Artery Risk Development in Young Adults Study. Am J Epidemiol, 2010, 171: 532-539.

36. Sesso HD, Cook NR, Buring JE, Manson JE, Gaziano JM. Alcohol consumption and the risk of hypertension in women and men. Hypertension, 2008, 51: 1080-1087.

37. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet, 1992, 339: 1523-1536.

38. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ, 1999, 319: 1523-1528.

39. Suzuki K, Elkind MS, Boden-Albala B et al. Moderate alcohol consumption is associated with better endothelial function: a cross sectional study. BMC Cardiovasc Disord, 2009, 9: 8.

40. Estruch R, Sacanella E, Badia E et al. Different effects of redwine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis, 2004, 175: 117-123.

41. Mukamal KJ, Cushman M, Mittleman MA, Tracy RP, Siscovick DS. Alcohol consumption and inflammatory markers in older adults: the Cardiovascular Health Study. Atherosclerosis, 2004, 173: 79-87.

42. Pai JK, Hankinson SE, Thadhani R, Rifai N, Pischon T, Rimm EB. Moderate alcohol consumption and lower levels of inflammatory markers in US men and women. Atherosclerosis, 2006, 186: 113-120.

43. Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Prior alcohol consumption and mortality following acute myocardial infarction. JAMA, 2001, 285: 1965-1970.

44. Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM. Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption. Proc Natl Acad Sci USA, 1998, 95: 8262-8267.

45. Churchill EN, Disatnik MH, Mochly-Rosen D. Time-dependent and ethanolinduced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilon PKC and activation of aldehyde dehydrogenase 2. J Mol Cell Cardiol, 2009, 46: 278-284.

46. Djousse L, Biggs ML, Mukamal KJ, Siscovick DS. Alcohol consumption and type 2 diabetes among older adults: the Cardiovascular Health Study. Obesity (Silver Spring), 2007, 15: 1758-1765.

47. Imamura F, Lichtenstein AH, Dallal GE, Meigs JB, Jacques PF. Confounding by dietary patterns of the inverse association between alcohol consumption and type 2 diabetes risk. Am J Epidemiol, 2009, 170: 37-45.

48. Ajani UA, Hennekens CH, Spelsberg A, Manson JE. Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians. Arch Intern Med, 2000, 160: 1025-1030.

49. Baliunas DO, Taylor BJ, Irving H et al. Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care, 2009, 32: 2123-2132.

50. Sierksma A, Patel H, Ouchi N et al. Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care, 2004, 27: 184-189.

51. Beulens JW, Rimm EB, Hu FB, Hendriks HF, Mukamal KJ. Alcohol consumption, mediating biomarkers, and risk of type 2 diabetes among middle-aged women. Diabetes Care, 2008, 31: 2050-2055.

52. Knott C, Bell S, Britton A. Alcohol сonsumption and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of more than 1.9 million individuals from 38 observational studies. Diabetes Care, 2015, 38: 1804-1812.

53. Polsky S, Akturk HK. Alcohol consumption, diabetes risk, and cardiovascular disease within diabetes. Curr Diab Rep, 2017, 17: 136.

54. Liangpunsakul S, Chalasani N. What should we recommend to our patients with NAFLD regarding alcohol use? Am J Gastroenterol, 2012, 107: 976-978.

55. Dunn W, Xu R, Schwimmer JB. Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease. Hepatology, 2008, 47: 1947-1954.

56. Zhu L, Baker SS, Gill C et al. Characterization of gut microbiomes in nonalcoholic steatohepati-tis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology, 2013, 57: 601-609.

57. Alkerwi A, Boutsen M, Vaillant M et al. Alcohol consumption and the prevalence of metabolic syndrome: a meta-analysis of observational studies. Atherosclerosis, 2009, 204: 624-635.

58. Djousse L, Arnett DK, Eckfeldt JH, Province MA, Singer MR, Ellison RC. Alcohol consumption and metabolic syndrome: does the type of beverage matter? Obes Res, 2004, 12: 1375- 1385.

59. Sogabe M, Okahisa T, Taniguchi T, Tomonari T, Tanaka T, Tanaka H. Light alcohol consumption plays a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome. Liver Int, 2015, 35: 1707-1714.

60. Takahashi H, Ono M, Hyogo H, Tsuji C, Kitajima Y, Ono N. Biphasic effect of alcohol intake on the development of fatty liver disease. J Gastroenterol, 2015, 50: 1114-1123.

61. Sinn DH, Gwak GY, Cho J, Son HJ, Paik YH, Choi MS et al. Modest alcohol consumption and carotid plaques or carotid artery stenosis in men with non-alcoholic fatty liver disease. Atherosclerosis, 2014, 234: 270-275.

62. Dunn W, Brunt EM, Sanyal AJ et al. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD) [abstr]. Hepatology, 2009, 50(Suppl): 390A.

63. Kanuri G, Landmann M, Priebs J, Spruss A, Löscher M, Ziegenhardt D et al. Moderate alcohol consumption diminishes the development of non-alcoholic fatty liver disease (NAFLD) in ob/ob mice. Eur J Nutr, 2016, 55: 1153-1164.

64. Bianchini F, Vainio H. Wine and resveratrol: mechanisms of cancer prevention? Eur J Cancer Prev, 2003, 12: 417-425.

65. Arranz S, Chiva-Blanch G, Valderas-Martínez P, Medina-Remón A, Lamuela-Raventós RM, Estruch R. Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients, 2012, 4: 759-781.

66. Tahbaz R, Schmid M, Merseburger AS. Prevention of kidney cancer incidence and recurrence: lifestyle, medication and nutrition. Curr Opin Urol, 2018, 28: 62-79.

67. Jarl J, Heckley G, Brummer J, Gerdtham UG.Time characteristics of the effect of alcohol cessation on the risk of stomach cancer - a meta-analysis. BMC Public Health, 2013, 13: 600. doi: 10.1186/1471-2458-13-600.

68. Klarich DS, Brasser SM, Hong MY. Moderate alcohol consumption and colorectal cancer risk. Alcohol Clin Exp Res, 2015, 39: 1280-1291.

69. Anderson LA, Cantwell MM, Watson RG, Johnston BT, Murphy SJ, Ferguson HR et al. The association between alcohol and reflux esophagitis, barrett’s esophagus, and esophageal adenocarcinoma. Gastroenterology, 2009, 136: 799-805.

70. Chao C. Associations between beer, wine, and liquor consumption and lung cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 2007, 16: 2436-2447.

71. Han X, Zheng T, Foss FM, Ma S, Holford TR, Boyle P et al. Alcohol consumption and non-hodgkin lymphoma survival. J Cancer Surviv, 2010, 4: 101-109.

72. Mikosch P. Alcohol and bone. Wien Med Wochenschr, 2014, 164: 15-24.

73. Gaddini GW, Turner RT, Grant KA, Iwaniec UT. Alcohol: A simple nutrient with complex actions on bone in the adult skeleton. Alcohol Clin Exp Res, 2016, 40: 657-671.

74. Papadimitriou N, Tsilidis KK, Orfanos P, Benetou V, Ntzani EE, Soerjomataram I et al. Burden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortium. Lancet Public Health, 2017, 2: e239-e246.

75. Marrone JA, Maddalozzo GF, Branscum AJ, Hardin K, Cialdella-Kam L, Philbrick KA et al. Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women. Menopause, 2012, 19: 974-979.

76. Wang J, Duan X, Li B, Jiang X. Alcohol consumption and risk of gallstone disease: a meta-analysis. Eur J Gastroenterol Hepatol, 2017, 29: e19-e28.

77. Sofi F, Macchi C, Casini A. Mediterranean diet and minimizing neurodegeneration. Curr Nutr Rep, 2013, 2: 75-80.

78. de Gaetano G, Costanzo S, Di Castelnuovo A, Badimon L, Bejko D, Alkerwi A et al. Effects of moderate beer consumption on health and disease: a consensus document. Nutr Metab Cardiovasc Dis, 2016, 26: 443-467.

79. Kojima G, Liljas A, Iliffe S, Jivraj S, Walters K. A systematic review and meta-analysis of prospective associations between alcohol consumption and incident frailty. Age Ageing, 2018, 47: 26-34.

80. Covas MI, Gambert P, Fito M, de la Torre R. Wine and oxidative stress: up-to-date evidence of the effects of moderate wine consumption on oxidative damage in humans. Atherosclerosis, 2010, 208: 297-304.

81. Artero A, Artero A, Tarín JJ, Cano A. The impact of moderate wine consumption on health. Maturitas, 2015, 80: 3-13.

82. Baur JA, Pearson KJ, Price NL et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006, 444: 337-342.

83. Xiang L, Xiao L, Wang Y, Li H, Huang Z, He X. Health benefits of wine: don’t expect resveratrol too much. Food Chem, 2014, 156: 258-263.

84. Di Castelnuovo A, Rotondo S, Iacoviello L, Donati MB, De Gaetano G. Metaanalysis of wine and beer consumption in relation to vascular risk. Circulation, 2002, 105: 2836-2844.

85. Nunez-Cordoba JM, Martinez-Gonzalez MA, Bes-Rastrollo M, Toledo E, Beunza JJ, Alonso A. Alcohol consumption and the incidence of hypertension in a Mediterranean cohort: the SUN study. Rev Esp Cardiol, 2009, 62: 633-641.

86. Araim O, Ballantyne J, Waterhouse AL, Sumpio BE. Inhibition of vascular smooth muscle cell proliferation with red wine and red wine poly-phenols. J Vasc Surg, 2002, 35: 1226-1232.

87. Flesch M, Schwarz A, Bohm M. Effects of red and white wine on endotheliumdependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol, 1998, 275(4 Pt 2): H1183-1190.

88. Corder R, Douthwaite JA, Lees DM et al. Endothelin-1 synthesis reduced by red wine. Nature, 2001, 414: 863-864.

89. Casani L, Segales E, Vilahur G, Bayes de Luna A, Badimon L. Moderate daily intake of red wine inhibits mural thrombosis and monocyte tissue factor expression in an experimental porcine model. Circulation, 2004, 110: 460-465.

90. Fuhrman B, Lavy A, Aviram M. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am J Clin Nutr, 1995, 61: 549- 554.

91. Gerhauser C. Beer constituents as potential cancer chemopreventive agents. Eur J Cancer, 2005, 41: 1941-1954.

92. Cleophas TJ. Wine, beer and spirits and the risk of myocardial infarction: a systematic review. Biomed Pharmacother, 1999, 53: 417-423.

93. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits. BMJ, 1996, 312: 731-736.

94. Gaziano JM, Gaziano TA, Glynn RJ et al. Light-to-moderate alcohol consumption and mortality in the Physicians’ Health Study enrollment cohort. J Am Coll Cardiol, 2000, 35: 96-105.

95. Doll R, Peto R, Hall E, Wheatley K, Gray R. Mortality in relation to consumption of alcohol: 13 years’ observations on male British doctors. BMJ, 1994, 309: 911-908.

96. Renaud SC, Gueguen R, Schenker J, d’Houtaud A. Alcohol and mortality in middle-aged men from eastern France. Epidemiology, 1998, 9: 184-188.

97. Thun MJ, Peto R, Lopez AD et al. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med, 1997, 337: 1705-1714.

98. Freiberg MS, Chang YF, Kraemer KL, Robinson JG, Adams-Campbell LL, Kuller LL. Alcohol consumption, hypertension, and total mortality among women. Am J Hypertens, 2009, 22: 1212-1218.

99. Schooling CM, Sun W, Ho SY et al. Moderate alcohol use and mortality from ischaemic heart disease: a prospective study in older Chinese people. PLoS One, 2008, 3: e2370.

100. Strandberg AY, Strandberg TE, Salomaa VV, Pitkala K, Miettinen TA. Alcohol consumption, 29-y total mortality, and quality of life in men in old age. Am J Clin Nutr, 2004, 80: 1366-1371.

101. Sempos CT, Rehm J, Wu T, Crespo CJ, Trevisan M. Average volume of alcohol consumption and all-cause mortality in African Americans: the NHEFS cohort. Alcohol Clin Exp Res, 2003, 27: 88-92.





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