Журнал "Медицинский совет" №11, 2018
В статье представлен обзор о роли витамина D в профилактическом лечении острых средних отитов у детей. Коротко дано патогенетическое обоснование действия витамина D на иммунную систему человека. Проанализированы причины актуальности применения препаратов витамина D в профилактике острых средних отитов у детей. Поставлены актуальные вопросы для дальнейшего изучения проблемы в педиатрической практике
M.P. Vorobyova, D.A. Tulupov, PhD in medicine, E.P. Karpova, MD, Prof, O.G. Naumov, PhD in medicine Russian Medical Academy of Continuing Postgraduate Education, Federal State Budgetary Educational Institution of Further Professional Education of the Ministry of Health of Russia, Moscow
Prospects for vitamin d in prevention of acute otitis media in children
The article presents an overview of the role of vitamin D in prevention of acute otitis media in children. It provides brief pathogenetic justification of the action of vitamin D on the human immune system. The reasons for the urgency of the use of vitamin D supplements in prevention of acute otitis media in children are analysed. Topical issues to further study the problem in paediatric practice are presented.
Список литературы
1. Holick MF. Vitamin D: a millennium perspective. J Cell Biochem, 2003, 88: 296-307.
2. Захарова И.Н., Дмитриева Ю.А., Яблочкова С.В. Современный взгляд на метаболизм и физиологические эффекты витамина D в организме человека. Вестник Алматинского государственного института усовершенствования врачей, 2013, 2: 27-31.
3. Laaksi I, Ruohola JP, Tuohimaa P, Auvinen A, Haataja R, Pihlajamäki H, Ylikomi T. An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr, 2007, 86: 714-717.
4. Ginde AA, Mansbach JM, Camargo CA. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med, 2009, 169: 384-390.
5. Снопов С.А. Механизмы действия витамина D на иммунную систему. Медицинская иммунология, 2014, 16(6): 499-530.
6. Najada AS, Habashneh MS, Khader M. The frequency of nutritional rickets among hospital-ized infants and its relation to respiratory diseases. J Trop Pediatr, 2004, 50: 364-368.
7. Williams B, Williams AJ, Anderson ST. Vitamin D deficiency and insufficiency in children with tuberculosis. Pediatr Infect Dis J, 2008, 27: 391- 396.
8. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr, 2008, 87: S1080-S1086.
9. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr, 2010, 91(5): 1255-1260.
10. Богомильский М.Р., Минасян В.С., Самсыгина Г.А. Острый средний отит у новорожденных и грудных детей. М., 2007.
11. Тулупов Д.А., Карпова Е.П. Острый средний отит у детей. Пособие для врачей. М.: «Петроруш». 2012. 24 c.
12. Venekamp RP, Damoiseaux RA, Schilder AG. Acute Otitis Media in Children. Am Fam Physician, 2017 Jan 15, 95(2): 109-110.
13. Granath A. Recurrent Acute Otitis Media: What Are the Options for Treatment and Prevention? Curr Otorhinolaryngol Rep, 2017, 5(2): 93-100.
14. Козлов Р.С., Кречикова О.И., Муравьев А.А., Миронов К.О. Платонов А.Е., Дунаева Е.А., Таточенко В.К., Щербаков М.Е., Родникова В.Ю., Романенко В.В., Сафьянов К.Н. Распространенность внебольничной пневмонии и острого среднего отита у детей до 5 лет в России Результаты исследования распространенности в России внебольничной пневмонии и острого среднего отита у детей в возрасте до 5 лет (PAPIRUS). Роль S. pneumoniae и H. influenzaeв этиологии данных заболеваний. Клиническая микробиология и антимикробная химиотерапия, 2013, 15(4): 246-260.
15. Leach AJ, Morris PS. Antibiotics for the prevention of acute and chronic suppurative otitis media in children. Cochrane Database Syst Rev, 2006, 4: CD004401.
16. Cheong KH, Hussain SS. Management of recurrent acute otitis media in children: systematic review of the effect of different interventions on otitis media recurrence, recurrence frequency and total recurrence time. J Laryngol Otol, 2012, 126(9): 874-85.
17. McDonald S, Langton Hewer CD, Nunez DA. Grommets (ventilation tubes) for recurrent acute otitis media in children. Cochrane Database Syst Rev, 2008, 4: CD004741.
18. Vlastarakos PV, Nikolopoulos TP. Grommets in otitis media with effusion: the most frequent operation in children. But is it associated with significant complications? Eur J Pediatr, 2007, 166(5): 385-391.
19. Boonacker CW, Rovers MM, Browning GG, Hoes AW, Schilder AG, Burton MJ. Adenoidectomy with or without grommets for children with otitis media: an individual patient data meta-analysis. Health Technol Assess, 2014, 18(5): 1-118.
20. Littorin N, Ahl J, Udden F, Resman F, Riesbeck K. Reduction of Streptococcus pneumoniae in upper respiratory tract cultures and a decreased incidence of related acute otitis media following introduction of childhood pneumococcal conjugate vaccines in a Swedish county. BMC Infect Dis, 2016, 16.
21. Fortanier AC, Venekamp RP, Boonacker CW, Hak E, Schilder AG, Sanders EA, Damoiseaux RA. Pneumococcal conjugate vaccines for preventing otitis media. Cochrane Database Syst Rev, 2014 Apr 2, 4: CD001480.
22. Sasaki A, Kunimoto M, Takeno S, Sumiya T, Ishino T, Sugino H, Hirakawa K. Influence of pneumococcal conjugate vaccines on acute otitis media in Japan. Auris Nasus Larynx, 2017, pii: S0385-8146(17)30516-3.
23. Casey JR, Adlowitz DG, Pichichero ME. New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. The Pediatric Infectious Disease Journal, 2010, 29(4): 304-309.
24. Pumarola F, Marès J, Losada I, Minguella I, Moraga F, Tarragó D, Aguilera U, Casanovas JM, Gadea G, Trías E, Cenoz S, Sistiaga A, García-Corbeira P, Pirçon JY, Marano C, Hausdorff WP. Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era. Int J Pediatr Otorhinolaryngol, 2013, 77(8): 1231-1236.
25. Dupont D, Mahjoub-Messai F, François M, Doit C, Mariani-Kurkdjian P, Bidet P, Bonacorsi S, Carol A, Bingen E. Evolving microbiology of complicated acute otitis media before and after introduction of the pneumococcal conjugate vaccine in France. Diagn Microbiol Infect Dis, 2010 Sep, 68(1): 89-92.
26. Norhayati MN, Ho JJ, Azman MY. Influenza vaccines for preventing acute otitis media in infants and children. Cochrane Database Syst Rev, 2017 Oct 17, 10: CD010089.
27. Di Pierro F1 Colombo M, Giuliani MG, Danza ML, Basile I, Bollani T, Conti AM, Zanvit A, Rottoli AS. Effect of administration of Streptococcus salivarius K12 on the occurrence of streptococcal pharyngo-tonsillitis, scarlet fever and acute otitis media in 3 years old children. Eur Rev Med Pharmacol Sci, 2016 Nov, 20(21): 4601-4606.
28. Gulani A, Sachdev HS. Zinc supplements for preventing otitis media. Cochrane Database Syst Rev, 2014, 29, 6: CD006639.
29. Azarpazhooh A, Lawrence HP, Shah PS. Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev, 2016, 8: CD007095.
30. Cayir A, Turan MI, Ozkan O. Serum vitamin D levels in children with recurrent otitis media. Eur Arch Otorhinolaryngol, 2014, 271(4): 689-693.
31. Cayir A, Turan MI, Ozkan O, Cayir Y. Vitamin D levels in children diagnosed with acute otitis media. J Pak Med Assoc, 2014, 64(11): 1274-1277.
32. Marchisio P, Consonni D, Baggi E, Zampiero A, Bianchini S, Terranova L, Tirelli S, Esposito S, Principi N. Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children. Pediatr Infect Dis J, 2013, 32(10): 1055-1560.
33. Walker RE, Bartley J, Camargo CA Jr, Flint D, Thompson JMD, Mitchell EA. Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study. Acta Paediatr, 2017, 106(9): 1487-1492.
