Журнал "Медицинский совет. Гастроэнтерология" №12, 2018
Е.А. Климов1,2,3, д.биол.н., А.В. Малахова1, Л.А. Коробейникова3, к.биол.н., Ю.Э. Азимова4, к.биол.н., О.И. Рудько1, к.биол.н., З.Г. Кокаева1, к.биол.н., И.М. Корсунская5, д.м.н., профессор, В.В. Соболев3,5,6, к.биол.н.
1 Московский государственный университет им. М.В. Ломоносова
2 ФГБНУ «Центр экспериментальной эмбриологии и репродуктивных биотехнологий», Москва
3 Университетская диагностическая лаборатория, Москва
4 Университетская клиника головной боли, Москва
5 Центр теоретических проблем физико-химической фармакологии Российской академии наук, Москва
6 ФГБНУ «Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова», Москва
Паническое расстройство является широко распространенным социально значимым заболеванием, генетическая природа которого крайне мало изучена. С тех пор как были обнаружены паникогенные свойства холецистокинина, ген этого нейропептида (ССK) и его рецепторов (CCKAR, ССK2R) активно изучаются. Целью настоящей работы была оценка частоты встречаемости семи однонуклеотидных замен в генах CCK, CCKAR и CCKBR в выборке больных с диагнозом паническое расстройство и контрольной выборке необследованных жителей Московского региона. Обнаружено достоверное увеличение частоты встречаемости аллеля Т однонуклеотидной замены 109С/Т (rs1805000) в гене CCKBR в выборке больных по сравнению с контролем, что позволяет предположить вовлеченность данной замены в этиологию панического расстройства. Также показана ассоциация комбинации аллелей -36Т CCK, -128Т CCKAR (rs11571842 и rs1800908, соответственно) с развитием панического расстройства.
Polymorphic variants of the cholecystokinergic system genes: associations with panic disorders
E.A. Klimov1,2,3, A.V. Malakhova1, L.A. Korobeinikova3, Yu.E. Azimova4, O.I. Rudko1, Z.G. Kokaeva1, I.M. Korsunskaya5, V.V. Sobolev3,5,6
1 M.V. Lomonosov Moscow State Medical University
2 Center for Experimental Embryology and Reproductive Biotechnology, Moscow
3 University Diagnostic Laboratory, Moscow
4 University Headache Clinic, Moscow
5 Center for Theoretical Problems of Physico-Chemical Pharmacology of the Russian Academy of Sciences, Moscow
6 I.I. Mechnikov Vaccine and Serum Research Institute, Moscow
Panic disorder is a widespread socially significant disease, which genetic nature is extremely poorly known. The gene of this neuropeptide (CCK) and its receptors (CCKAR, CCK2R) have being actively studied since the discovery of panicogenic properties of cholecystokinin. The purpose of this work was to estimate the degree of incidence of seven single nucleotide substitutions in the CCK, CCKAR and CCKBR genes in the population of patients diagnosed with panic disorder and a control population consisting of unexamined residents of the Moscow region. A significant increase in the degree of incidence of the T allele of the single nucleotide substitution 109C/T (rs1805000) in the CCKBR gene was identified in the patient population as compared with the controls, prompting suggestions that this substitution is involved in the aetiology of panic disorder. It also demonstrated the association of the combination of alleles -36T CCK, -128T CCKAR (rs11571842 and rs1800908, respectively) with the development of a panic disorder.
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