Гипопитуитаризм у детей и подростков

Журнал "Медицинский совет. Педиатрия" №2, 2019

Mariya V. Vorontsova, Federal State Budgetary Institution «National Medical Research Center of Endocrinology» of the Ministry of Health of the Russian Federation

Рост – один из наиболее важных показателей здоровья ребенка. Данная статья посвящена гипопитуитаризму – эндокринному заболеванию с изолированным дефицитом гормона роста (соматотропный гормон) или множественным дефицитом тропных гормонов гипофиза. Описывается этиология, генетические механизмы развития заболевания, приведена классификация. Подробно описана клиническая картина и ее варианты, диагностический поиск, а также приведены критерии направления к эндокринологу. Отдельная глава посвящена подробному обсуждению стимуляционных проб, критериев их назначения и выбора пробы, а также поднят вопрос о ретестировании. Приводится схема лечения гипопитуитаризма в соответствии с отечественным и зарубежными стандартами. Приведен перечень необходимых обследований в рамках наблюдения ребенка с гипопитуитаризмом.

Hypopituitarism in children and adolescents

Mariya V. Vorontsova, Cand.of Sci.(Med.), a pediatric endocrinologist, a researcher of Federal State Budgetary Institution «National Medical Research Center of Endocrinology» of the Ministry of Health of the Russian Federation

Growth is one of the most important indicators of child health. This article focuses on hypopituitarism, an endocrine disease with isolated growth hormone deficiency (somatotropic hormone) or multiple deficiency of the pituitary tropic hormones. The authors describe the etiology, genetic mechanisms of the disease development and provide the classification. The clinical picture and its variants, the diagnostic search are described in detail, and the criteria of referral to the endocrinologist are given. A separate chapter is devoted to the detailed discussion of stimulation samples, criteria for samples selection and scheduling. The authors also raise an issue of retesting. The scheme of treatment of hypopituitarism in accordance with domestic and foreign standards is provided. A list of necessary examinations in the framework of observation of a child with hypopituitarism is given.

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