Применение антибиотиков у новорожденных: влияние на желудочно-кишечную микрофлору и отдаленные результаты


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Применение антибиотиков у новорожденных: влияние на желудочно-кишечную микрофлору и отдаленные результаты

Журнал "Медицинский совет. Педиатрия" №17, 2018

Иван Ванденплас, Университетская клиника Брюсселя, Брюссельский свободный университет (Vrije), Бельгия

Сбалансированный желудочно-кишечный микробиом имеет решающее значение для развития иммунной системы. Применение антибиотикотерапии у младенцев часто приводит к кишечному дисбиозу. В данной статье приведены факты, убеждающие в том, что применение антибиотиков у детей грудного и раннего возраста отражается на состоянии их здоровья в дальнейшем. Назначение антибиотикотерапии в детском возрасте должно быть хорошо продумано, т. к. доказано их негативное влияние на желудочно-кишечный тракт – способность вызывать диарею, кроме того, прием антибиотиков имеет отдаленные последствия: избыточный вес, синдром раздраженного кишечника (СРК), аллергические заболевания. Заключение: следует взвешивать необходимость и последствия приема антибиотиков в грудном и раннем детском возрасте.

Yvan Vandenplas, Brussels University Hospital, Free University of Brussels (Vrije), Belgium 

The use of antibiotics in newborns: effects on gastrointestinal microbiome and long-term results 

A balanced gastrointestinal microbiome is crucial for the development of the immune system. The use of antibiotic therapy in infants often leads to intestinal dysbiosis. This article presents a convincing argument that the use of antibiotics in infants and young children affects their health in the future. The purpose of antibiotic therapy in childhood should be well thought out, because its negative effect on the gastrointestinal tract - the ability to cause diarrhoea, has been proven, and, in addition, antibiotics have long-term effects: overweight, irritable bowel syndrome (IBS), allergic diseases. Conclusion: clinicians should weigh the need and consequences of using antibiotics in infancy and early childhood. 

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